Total testosterone and sex hormone-binding globulin (SHBG) levels were inversely associated with the risk of cardiovascular (CV) events in a population-based study of 2,416 men in Sweden aged 69-81 years.

For the 485 CV events that occurred over a median five-year follow-up, men in the highest quartile of testosterone—550 ng/dL or greater—had a 30% lower risk than men in the lower three quartiles.

In models that included both testosterone and SHBG, testosterone but not SHBG predicted CV risk, according to a report in the Journal of the American College of Cardiology (2011;58:1674-1681).

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