A meta-analysis of data from 1.1 million adults from 25 general-population cohorts, seven high-risk cohorts (of vascular disease), and 13 CKD cohorts indicated that the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates GFR than does the Modification of Diet in Renal Disease (MDRD) Study equation.
Compared with the MDRD Study equation, the CKD-EPI equation reclassified 24.4% of general-population participants, 15.4% of high-risk patients, and 6.6% of CKD patients to a higher eGFR category, lowering the prevalence of CKD in all cohorts except that of the elderly.
Approximately 0.6% of participants were reclassified to a lower eGFR category, and the prevalence of CKD stages 3 to 5 (estimated GFR below 60 mL/min/1.73 m2) was reduced from 8.7% (MDRD) to 6.3% (CKD-EPI) in the general population and from 17.7% (MDRD) to 14.6% (CKD-EPI) in the high-risk cohorts, researchers reported in the Journal of the American Medical Association (2012;307:1941-1951).
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