Recent population-based study findings indicate that circumcision before first sexual intercourse is associated with a reduction in the relative risk of prostate cancer (PCa), perhaps by preventing sexually transmitted infections. Jonathan L. Wright, MD, and coinvestigators found that among 1,754 cases and 1,645 controls, PCa was 15% less likely to develop in men who were circumcised before first sexual intercourse than uncircumcised men, according to an online report in Cancer.

The new findings are in line with an infectious/inflammatory pathway that may be involved in PCa risk, according to Dr. Wright, Assistant Professor of Urology at the University of Washington School of Medicine in Seattle.