Daily aspirin use, even at low doses, may reduce mortality among men with high-risk nonmetastatic prostate cancer (PCa), according to research published online ahead of print in the Journal of Clinical Oncology.

Eric J. Jacobs, PhD, of the American Cancer Society in Atlanta, and colleagues analyzed data for men diagnosed with nonmetastatic prostate cancer to assess the association between daily aspirin use and prostate cancer-specific mortality (PCSM). The men were enrolled in the Cancer Prevention Study-II Nutrition Cohort between 1992 or 1993 and June 2009, and followed up through 2010.

On multivariate analysis, neither prediagnosis nor postdiagnosis daily use of aspirin showed a statistically significant association with PCSM compared with no aspirin use. Among men diagnosed with high-risk cancers (clinical stage T3 or higher and/or Gleason score 8 or higher), postdiagnosis daily aspirin use was associated with a 40% decreased risk of PCSM. In this subgroup, no difference in mortality risk was observed according to aspirin dose.

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“A randomized trial of aspirin among men diagnosed with nonmetastatic prostate cancer was recently funded,” the authors wrote. “Our results suggest any additional randomized trials addressing this question should prioritize enrolling men with high-risk cancers and need not use high doses.”