Recurrent urinary tract infections (UTIs) are associated with poorer graft and patient outcomes compared with noncurrent UTIs, researchers reported.
In a retrospective study of 2469 kidney transplant recipients, Nicholas S. Britt, MD, and colleagues at Barnes-Jewish Hospital in St. Louis, Missouri, compared graft and patient outcomes and multidrug-resistance rates. Of these, 1835 (74.3%) had no UTIs, 465 (18.8%) had non-recurrent UTIs, and 169 (6.8%) had recurrent UTIs. Recipients with recurrent UTIs had 1.4-fold and 2-fold increased risk of graft failure than those with no UTIs, Dr Britt’s group reported online in Nephrology Dialysis Transplantation (2017;32:1758-1766). Patients with recurrent UTIs had an 87% increase risk of death compared with those who had non-recurrent UTIs. In addition recurrent UTIs were more 49% more likely to be caused by multidrug-resistant Gram-negative bacteria.
The investigators defined recurrent UTIs as 2 or more UTIs in any 6-month period or 3 or more UTIs in any 12-month period.
Britt NS, Hagopian JC, Brennan DC, et al. Effects of recurrent urinary tract infections on graft and patient outcomes after kidney transplantation. Nephrol Dial Transplant. 2017;32:1758-1766. doi:10.1093/ndt/gfx237