Renal transplant recipients with prediabetes are an increased risk for cardiovascular disease (CVD), according to a new study.

In these patients, prediabetes at 12 months was associated with a significant 2.1-fold increased risk of fatal and nonfatal cardiovascular (CV) events beyond 12 months, investigators reported in Kidney International. The magnitude of the increased risk was similar to that of diabetes, the presence of which at 12 months was associated with a significant 2.4-fold increased risk, according to the investigators.

“Since prediabetes is potentially a reversible condition, there is an opportunity to prevent cardiovascular disease in this population,” a team led by Esteban Porrini, MD, of Instituto de Tecnologías Biomédicas (ITB), University of La Laguna, Tenerife, Spain, concluded.

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The study included 603 renal transplant recipients without diabetes after transplantation. Patients had a median age of 49 years, and 66% were male. The study population had median follow-up duration of almost 8.4 years. At 12 months, 163 patients (27%) had prediabetes, 98 (16%) had diabetes, and 342 (57%) had normal glucose metabolism. The incidence of CV events was significantly higher among patients with prediabetes and diabetes at 12 months than patients without these conditions (17% and 20% vs 7%, respectively).

Reference

Porrini E, Díaz JM, Moreso F, et al. Prediabetes is a risk factor for cardiovascular disease following renal transplantation. Kidney Int. 2019. https://doi.org/10.1016/j.kint.2019.06.026