(HealthDay News) — Overall, about 14.7% of living kidney donors have postdonation events, most of which occur more than 2 years after donation, according to a study published online in JAMA Network Open.

Jieming Chen, PhD, from the University of California in San Francisco, and colleagues conducted a cohort study on data from the transplant data set derived from 27 clinical studies from the ImmPort database. Data from 20 ImmPort clinical studies were curated, and 11,263 living donors (LDs) were studied. Data were analyzed for 9558 living kidney donors with postdonation data.

The researchers found that 14.7% of LDs had postdonation events, most commonly hypertension, diabetes, proteinuria, and postoperative ileus (8.4, 2, 1.8, and 1.5%, respectively). Overall, 269 events occurred before 2 years postdonation. Most (90.2%) of the 1746 events that took place 2 years or more after donation were nonsurgical; they tended to occur 2 to 40 years after donation (odds ratio, 38.3).

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“Ultimately, we want to encourage and empower potential LDs, not only in seeing the benefits of living donation in saving the lives of their loved ones and strangers but also in better understanding the risks and making more informed choices when deciding to become living donors,” the authors write.

Several authors disclosed financial ties to the pharmaceutical and technology industries.


Chen J, Bhattacharya S, Sirota M, et al. Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets. JAMA Netw Open. 2019;2(4):e191851. doi:10.1001/jamanetworkopen.2019.1851