SAN FRANCISCO—Living kidney donors have a modestly increased long-term risk of gout, researchers reported at the 2014 World Transplant Congress.

A team led by Ngan N. Lam, MD, of the London Health Sciences Centre in London, Ontario, studied 1,988 living kidney donors and 19,880 matched healthy non-donors who were followed for a median of 8.4 years. The median at the index date of the donors and matched controls was 43 years. Gout developed in significantly more donors than non-donors (3.4% vs. 2.0%), a difference that translated into a 60% increased risk of gout among living donors, according to a poster presentation. In addition, significantly more donors than non-donors received prescriptions of the gout medicines allopurinol or colchicine (3.8% vs. 1.3%), which translated into a 3.2 times increased likelihood of a gout medication prescription.

“This information can be shared with potential donors and their recipients as part of the informed consent process,” the authors concluded.

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Dr. Lam and her colleagues explained that decreases in glomerular filtration rate result in less uric acid excretion and thus a higher serum uric acid level. As early as 6 months after nephrectomy, they noted, living kidney donors have an 8.2% higher serum uric acid level compared with non-donor controls and a 20% higher serum uric acid level a mean 7 years after nephrectomy.