Organs can become significantly damaged during transplantation, but a new article published in the BJS (British Journal of Surgery) offers a protective strategy that could keep them safe and allow them to function optimally after the procedure. When an organ is transplanted from a donor to a recipient, there is a period of time when the organ is deprived of normal blood flow.
While this in itself can cause tissue damage, additional damage may also occur when blood flow is restored to the organ due to a high risk of blood clotting. Investigators led by Thierry Hauet, MD, PhD, of the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Poitiers, and the Centre Hospitalier Universitaire (CHU) de Poitiers, in France, wondered whether anticoagulants or “blood thinners” might help protect transplant organs against these effects.
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