Remission of proteinuria in patients with diffuse proliferative lupus nephritis(LN) is associated with a good prognosis, South Korean researchers reportedonline ahead of print in Lupus.
A team led by Ho Jun Chin, MD, of Seoul National University Bundang Hospitalstudied 26 men and 167 women with biopsy-confirmed diffuse proliferative LN.Patients had a mean age of 31.2 years at renal biopsy. During follow-up, 82 (42.5%)patients experienced proteinuric remission and 111 did not.Results showed that patients who achieved proteinuric remission had a decreasedrisk of death, incidence end-stage renal disease (ESRD), and a composite outcomecompared with those who did not have remission.
During a mean follow-up of157.9 months, among patients who achieved proteinuric remission, 1 (1.2%) died,1 (1.2%) progressed to ESRD, and 2 (2.4%) had composite outcomes. Amongpatients without remission, 9 (8.1%) died, 24 (21.6%) progressed to ESRD, and 30(27%) had composite outcomes.