Lupus Nephritis

Obinutuzumab Gets Breakthrough Status for Treatment of Lupus Nephritis

Publish Date September 19, 2019

The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to obinutuzumab (Genentech), a CD20-directed cytolytic antibody, for the treatment of adults with lupus nephritis. The designation was based on data from the phase 2 NOBILITY study that compared the efficacy and safety of obinutuzumab, in combination with mycophenolate mofetil (MMF) or mycophenolic acid…

Good Renal Transplant Outcomes Reported in Lupus Nephritis Cases

Publish Date August 23, 2019

In a small study, patients with lupus nephritis who underwent renal transplantation had 5-year graft and patient survival rates of 76.3% and 92.5%, respectively.

Epidemiologic Study Compares SLE Manifestations in Different Racial Groups

Publish Date June 6, 2019

Investigators examined racial/ethnic differences in manifestations of lupus and in the timing and risk of developing severe manifestations.

CDC: Racial Disparity Seen With Lupus-Related Deaths

Publish Date May 15, 2019

Deaths among blacks occur sooner after diagnosis and at younger age compared with whites

Adverse Childhood Experiences Linked to Worse Lupus Outcomes

Publish Date May 13, 2019

More adverse childhood experiences associated with depression, poor overall health for those with SLE

Elevated Fracture Risk Observed in SLE, Lupus Nephritis

Publish Date March 26, 2019

Patients with systemic lupus erythematosus were at greater risk for fractures compared with controls.

Lupus Nephritis Therapy Response Predicts Survival Odds

Publish Date February 4, 2019

Complete response to induction therapy is associated with significant 82% decreased odds of death at 12 months.

Kidney Transplantation Ups Survival in Lupus Nephritis Cases

Publish Date January 24, 2019

In a nationwide study, renal transplant recipients with lupus nephritis had a 70% lower risk for all-cause mortality than nonrecipients.

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

Publish Date January 16, 2019

Using electrochemiluminescence, researchers found 5 urinary proteins that have “reasonable specificity” for lupus nephritis.

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

Publish Date December 18, 2018

Researchers observed comparable long-term outcomes between patients with late- and early-onset lupus nephritis.