The triglyceride-glucose index can predict hyperuricemia risk in patients with diabetic kidney disease, a new study finds.

The index is a simple tool calculated from triglyceride levels and fasting plasma glucose that may reflect insulin resistance, Pei Yu, MD, of Tianjin Medical University in China, and colleagues explained.

In a cross-sectional study 6471 patients, 24% of men and 13.4% of women had hyperuricemia, defined as a serum uric acid level of 7 mg/dL or greater. Hyperuricemia prevalence significantly increased with increasing quartiles of the triglyceride-glucose index: from 13.9% in quartile 1 to 17.2%, 18.8%, and 28.5% in quartiles 2-4, respectively. In adjusted multivariate logistic regression, the odds of hyperuricemia significantly increased 1.4-, 1.7-, and 4.5-fold, respectively, for patients with a triglyceride-glucose index in quartiles 2, 3, and 4 compared with quartile 1, Dr Yu and colleagues reported in Scientific Reports.

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The investigators also longitudinally examined hyperuricemia risk using a separate cohort of 3634 patients, of whom 970 developed hyperuricemia over a median 23 months. In a fully adjusted model, hyperuricemia risk increased 1.7-, 2.2-, and 2.5-fold for patients in quartiles 2, 3, and 4 of the triglyceride-glucose index compared with quartile 1, Dr Yu’s team reported.

Only a small proportion of the study population (13.1%) had significantly impaired kidney function (estimated glomerular filtration rate less than 60 mL/min/1.73 m2).

“Along with other known risk factors, providing simpler and more economical options that can distinguish high-risk populations to implement early stage management may help reduce the occurrence of hyperuricemia and related diseases,” Dr Yu’s team concluded.

The study lacked data on smoking, alcohol consumption, diet, use of uric acid-lowering drugs and other medications that may lower uric acid levels, diabetes duration, and socioeconomic factors, all of which may affect uric acid levels.


Li Q, Shao X, Zhou S, et al. Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease. Sci Rep. 2022 Nov 21;12(1):19988. doi:10.1038/s41598-022-23478-1