The Dietary Approaches to Stop Hypertension (DASH) eating plan may be among the strategies to reduce serum uric acid levels.
In a systematic review and meta-analysis of 4 randomized controlled trials evaluating the DASH diet including 590 adults, serum uric acid significantly decreased by a mean difference of 0.25 mg/dL after at least 4 weeks on the diet, Mahsa Mahjani, MD, of the Alborz University of Medical Sciences in Alborz, Iran, and colleagues reported in Scientific Reports. A meta-analysis of 6 trials of a ketogenic diet including 267 adults showed no significant changes in serum uric acid, but further research is needed.
DASH diets included fruits, vegetables, and low-fat dairy foods and reduced consumption of saturated fat, total fat, and cholesterol along with whole grains, poultry, fish, and nuts and restricted red meat, sweets, and sugar-containing beverages. Approximately 40% of patients in the trial had baseline hyperuricemia and 45% had hypertension.
“DASH diet encompasses nutrients that are known to be inversely associated with [uric acid] concentration. Foods containing lower glycemic index carbohydrates (e.g., dairy products and some fruits) have reduced UA independent from changes in glucose and insulin levels,” Dr Mahjani’s team wrote.
These study results are preliminary. The investigators recommended future studies to evaluate the DASH diet dose and serum uric acid response. They also recommended analyses of other dietary interventions such as Mediterranean or vegetarian diets.
Gohari S, Ghobadi S, Jafari A, Ahangar H, Gohari S, Mahjani M. The effect of dietary approaches to stop hypertension and ketogenic diets intervention on serum uric acid concentration: a systematic review and meta-analysis of randomized controlled trials. Sci Rep. 13:10492. Published online June 28, 2023. doi:10.1038/s41598-023-37672-2