Allopurinol treatment for hyperuricemia may improve kidney function, according to a study of male veterans.
In a study of patients at the VA New York Harbor Healthcare System, Aneesa Krishnamurthy, DO, of SUNY Downstate Medical Center in Brooklyn, New York, and colleagues compared 50 men with hyperuricemia (serum uric acid level greater than 7 mg/dL) newly started on allopurinol with a control group of 50 hyperuricemic men not treated with allopurinol and matched by age, race, and estimated glomerular filtration rate (eGFR). The average follow-up was 3.4 years.
On average, patients treated with a mean 221 mg/day dose of allopurinol achieved a significant 11.9 mL/min/1.73 m2 higher eGFR compared with controls, Dr Krishnamurthy’s team reported in a paper published online ahead of print in the Journal of Clinical Rheumatology. The allopurinol group had a significant 0.10 mg/dL lower final creatinine level than controls after adjusting for initial creatinine level and age.
“Clinicians should consider this potential benefit of allopurinol in the treatment of patients with hyperuricemia, those with overall maintained renal function,” the investigators concluded in their paper.