(HealthDay News) — For overweight African-Americans with vitamin D deficiency, arterial stiffness is improved by vitamin D3 supplementation in a dose-response manner, according to a study published online in PLOS ONE.
Anas Raed, MD, from Augusta University in Georgia, and colleagues examined the dose-response effects of vitamin D3 supplementation on arterial stiffness in 70 overweight African-Americans with serum 25-hydroxyvitamin D (25[OH]D) levels ≤20 ng/mL. Participants were randomized to monthly supplementation of 18,000 IU (~600 IU/day), 60,000 IU (~2,000 IU/day), or 120,000 IU (~4,000 IU/day) of vitamin D3 or placebo for 16 weeks (17, 18, 18, and 17 participants, respectively).
The researchers observed a dose-response increase in serum 25(OH)D concentrations between the groups with vitamin D3 supplementation. For carotid-femoral pulse wave velocity (PWV), there was a significant downward linear trend, with mean changes in carotid-femoral PWV of 0.13 m/s for placebo, and 0.02, −0.11, and −0.70 m/s for the 600, 2000, and 4000 IU/day groups, respectively. For carotid-radial PWV, the findings were similar, with mean changes of 0.24 m/s for placebo, and 0.09, −0.57, and −0.61 m/s for the 600, 2,000, and 4,000 IU/day groups, respectively.
“Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African-Americans with vitamin D deficiency,” the authors write.
Raed A, Bhagatwala J, Zhu H, et al. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS One. doi:10.1371/journal.pone.0188424