Researchers have found a relationship between nocturnal polyuria (NP) and blood pressure that rises or fails to fall at night.

Of 194 patients from their institution who experience 2 or more voids nightly, 67% had NP, Wataru Obara, MD, of Iwate Medical University, and colleagues reported in Lower Urinary Tract Symptoms. Reduced functional bladder capacity explained symptoms in only a minority overall (13.4%), indicating that bladder storage problems were likely well treated.

NP appeared less well treated. As nocturia episodes increased, the proportion of those with NP also increased. For example, all men complaining of 5 or more nocturia episodes nightly had NP. The investigators found no significant differences in age, lower urinary tract symptoms, or complications between those with and without NP.

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A subset of 17 NP and 17 non-NP patients underwent ambulatory blood pressure monitoring. Significantly more men with NP had non-dipping blood pressure than men with other causes of nocturia (77% vs 41%). NP patients also were more likely to use 2 or more antihypertensive medications.

Non-dipping blood pressure might be a risk factor for NP, according to the team, although they could not prove a cause and effect relationship. “We suggest that treatment for non-dipping blood pressure may improve NP,” Dr Obara and his collaborators concluded.

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Takayama M, Omori S, Iwasaki K, et al. Relationship between nocturnal polyuria and non-dipping blood pressure in male patients with lower urinary tract symptoms. LUTS 2018:1-5. DOI: 10.1111/luts.12225