(HealthDay News) — Heart failure is not associated with an increased risk of cancer, according to a study published in the Journal of the American College of Cardiology.

Senthil Selvaraj, MD, from the University of Pennsylvania in Philadelphia, and colleagues used data from the Physicians’ Health Studies I and II (1982-1995 and 1997-2011) to assess whether heart failure is associated with cancer incidence and cancer-specific mortality.

The researchers found that 1420 of 28,341 participants developed heart failure. Over a median 19.9 years of follow-up, a total of 7363 cancers developed. heart failure was not associated with cancer incidence in either unadjusted (hazard ratio, 0.92; 95% confidence interval, 0.8 to 1.08) or adjusted analysis (hazard ratio, 1.05; 95% confidence interval, 0.86 to 1.29). Furthermore, there was no association between heart failure and site-specific cancer incidence or cancer-specific mortality.

Continue Reading

“In contrast to recent studies suggesting an increased risk of cancer among heart failure patients, we found that heart failure was not associated with cancer risk using the time-varying method,” the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Related Articles


Selvaraj S, Bhatt DL, Claggett B, et al. Lack of Association Between Heart Failure and Incident Cancer. J Am Coll Cardiol. 2018 April;71(14). DOI: 10.1016/j.jacc.2018.01.069 

Boffetta P and Malhotra J. Impact of Heart Failure on Cancer Incidence: A Complicated Question. J Am Coll Cardiol. 2018 April;71(14). DOI: 10.1016/j.jacc.2018.02.015