Changes in left ventricular mass index (LVMI) may predict the likelihood of new-onset microalbuminuria (MA) in patients with newly diagnosed hypertension, Greek researchers found.
In a prospective study of 207 nondiabetic patients with normal urinary albumin levels, each 23.3 g/m2 increment in LVMI was associated with a 15% increased risk of new-onset MA, whereas LVMI reduction and blood pressure (BP) control each was associated with a 100% decreased risk of MA, according to an online report in the American Journal of Hypertension.
The study population of 132 men and 75 women had a mean age of about 51 years and baseline office BP of 148/96 mm Hg. The follow-up period was 3.3 years. At baseline and last follow-up visit, all patients underwent office and 24-hour ambulatory BP monitoring, albumin to creatinine ratio (ACR) determination, and echocardiographic assessment of LVMI.
All patients received antihypertensive therapy during follow up. Eirini Andrikou, MD, and colleagues at the University of Athens, defined MA as an ACR between 20 and 300 mg/g for men and 30-300 mg/g for women and effective BP control as an office BP below 140/90 in 75% or more of visits. They defined LVMI reduction as a 15% of greater decline in LVMI at the end of follow-up compared with baseline.