(HealthDay News) — A “malignant” subphenotype of left ventricular hypertrophy (LVH) with minimal elevations in cardiac biomarkers is associated with an increased risk for heart failure, with some of the excess risk for heart failure among blacks explained by a higher prevalence of malignant LVH, according to a study published online in Circulation.

Alana A. Lewis, MD, from the University of Texas Southwestern Medical Center in Dallas, and colleagues pooled data from 15,710 participants without prevalent cardiovascular disease from 3 population-based cohort studies.

The researchers found that heart failure occurred in 3.3% of participants during the 10-year follow-up period, with rates of 5.2% in black men, 3.8% in white men, 3.2% in black women, and 2.2% in white women. Compared with white men and women, the prevalence of malignant LVH was 3-fold higher among black men and women. The adjusted hazard ratio for heart failure was 2.8 for those with malignant LVH and 0.9 for those with LVH and normal biomarkers compared with participants without LVH; findings were similar in each race/sex subgroup. In mediation analyses, the excess hazard for heart failure among black men (33%) and black women (11%) was explained by the higher prevalence of malignant LVH in blacks.

“We hope these findings can help cardiologists identify those at higher risk for developing heart failure and intervene earlier,” Lewis said in a statement.

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Several authors disclosed financial ties to the pharmaceutical industry.


Lewis AA, Ayers CR, Selvin E, et al. Racial Differences in Malignant Left Ventricular Hypertrophy and Incidence of Heart Failure: A Multi-Cohort Study. Circ.

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