(HealthDay News) — Intensive blood pressure (BP) reduction for acute intracerebral hemorrhage (ICH) may increase the risk for death or disability in some patients with renal impairment, according to a study published online in Neurology.
Mayumi Fukuda-Doi, MD, PhD, from the National Cerebral and Cardiovascular Center in Suita, Japan, and colleagues conducted post-hoc analyses using data from 1000 participants in the ATACH-2 randomized trial to assess whether the estimated glomerular filtration rate (eGFR) affects clinical outcomes or modifies the efficacy of intensive systolic blood pressure control (target, 110 to 139 mm Hg) against the standard (target, 140 to 179 mm Hg) among patients with ICH.
The researchers found that compared with normal eGFR (≥90 mL/min/1.73 m2), there were higher odds of death or disability among those with eGFR values of <60 mL/min/1.73 m2 (adjusted odds ratio [OR], 2.02; 95% confidence interval [CI], 1.25 to 3.26) but not among those with eGFR values of 60 to 89 mL/min/1.73 m2 (OR, 1.01; 95% CI, 0.70 to 1.46). In the intensive BP control arm, the odds of death or disability were higher among patients with decreased eGFR (OR for eGFR values of ≥90, 0.89 [95% CI, 0.55 to 1.44]; for eGFR 60 to 89, 1.13 [95% CI, 0.68 to 1.89]; for eGFR <60 mL/min/1.73 m2, 3.60 [95% CI, 1.47 to 8.80]; P for interaction = 0.02).
“At present, renal function should be considered when deciding the optimal blood pressure range for each patient,” Fukuda-Doi said in a statement.
Several authors disclosed financial ties to the pharmaceutical industry.