(HealthDay News) — For patients with heart failure, influenza infection is associated with increased in-hospital morbidity and mortality, according to a study published online in JACC: Heart Failure.

Muhammad S. Panhwar, MD, from the Case Western Reserve University School of Medicine in Cleveland, and colleagues queried the 2013 to 2014 National Inpatient Sample database for adult patients admitted with heart failure with and without concomitant influenza infection. Patients were matched using propensity score matching.

The researchers found that 0.67% of the 8,189,119 all-cause hospitalizations in patients with heart failure involved concomitant influenza infection. They observed a higher incidence of in-hospital mortality (6.2 vs 5.4%; odds ratio, 1.15), acute respiratory failure (36.9 vs 23.1%; odds ratio, 1.95), acute respiratory failure requiring mechanical ventilation (18.2 vs 11.3%; odds ratio, 1.75), acute kidney injury (30.3 vs 28.7%; odds ratio, 1.08), and acute kidney injury requiring dialysis (2.4 vs 1.8%; odds ratio, 1.37) for patients with concomitant influenza. Longer mean length of stay was seen for patients with influenza (5.9 vs 5.2 days), but average hospital costs were similar ($12,137 vs $12,003).

“Although the exact extent to which influenza infection contributes to morbidity, and mortality, in already compromised patients with heart failure has been difficult to estimate, the results of this study make it clear that during the winter months this contribution is neither negligible nor neglectable,” write the authors of an accompanying editorial.

Several authors disclosed financial ties to the pharmaceutical and publishing industries.

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References

Panhwar MS, Kalra A, Gupta T, Kolte D, Khera S, Bhatt DL, and Ginwalla M. Effect of Influenza on Outcomes in Patients with Heart Failure. JACC: Heart Fail. January 2019. DOI:10.1016/j.jchf.2018.10.011

Vardeny O and Solomon SD. Influenza and Heart Failure: A Catchy Comorbid Combination. JACC: Heart Fail. January 2019. DOI:10.1016/j.jchf.2018.11.008