People who have genetic variants tied to low production of 25-hydroxyvitamin D (25[OH]D) have an increased risk of hypertension, according to a study published online ahead of print in The Lancet Diabetes & Endocrinology.

Karani S. Vimaleswaran, PhD, from University College London, and colleagues used meta-analyzed data for up to 108,173 individuals from 35 studies in the D-CarDia collaboration. The authors sought to investigate associations between the allele score (a 25[OH]D synthesis score based on variants of genes that affect 25[OH]D synthesis or substrate availability) and blood pressure measurements.

In phenotypic analyses (up to 49,363 individuals), the researchers found that increased 25(OH)D concentration was associated with a significant decrease in systolic blood pressure and reduced odds of hypertension, but not with decreased diastolic blood pressure. Each 25(OH)D-increasing allele of the synthesis score in meta-analyses (146,581 individuals) was associated with a significant change of 0.10 mm Hg in systolic blood pressure and a significant change of 0.08 mm Hg in diastolic blood pressure. In a separate meta-analysis (142,255 individuals), the synthesis score was associated with a significantly reduced odds of hypertension.

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