Drug Treats Hyperphosphatemia Without Binding Phosphate
In a phase 3 trial, tenapanor, which reduces paracellular phosphate transport in the intestine, lowered elevated serum phosphorus in patients on hemodialysis.
Hyperphosphatemia
HYPERPHOSPHATEMIA
Elevated Phosphate Linked With Mortality in Peritoneal Dialysis
In a new study, patients with serum phosphate levels above 1.78 mmol/L at the start of peritoneal dialysis had a nearly 2-fold increased risk of death.
Activated Charcoal May Delay Hyperphosphatemia
In a 2-phased trial, hyperphosphatemia and is sequelae developed in a smaller proportion of patients taking activated charcoal compared with placebo recipients.
SGLT2 Inhibitor Increases Serum Phosphate, PTH, and FGF23
Study supports the hypothesis that altered tubular phosphate handling drives the increase in serum phosphate during SGLT2 inhibition.
Switching to Iron-Based Binder Improves Phosphorus Control
In 2 studies, roughly a third of hemodialysis patients achieved within-range serum phosphate levels after converting to sucroferric oxyhydroxide from another phosphate binder.
Replacing Meat With Egg White May Help Control Hyperphosphatemia
In a small study of hemodialysis patients, substituting egg white for meat and fish in 3 meals per week resulted in a significant decrease in serum phosphate.
Phosphate Binders Do Not Interfere With Nutrition
In a small study of patients on maintenance hemodialysis, phosphate binder use did not affect appetite, food intake, or malnutrition-inflammation score.
Serum Phosphate at Dialysis Start Tied With Mortality
In a Japanese study, patients with the lowest serum phosphate levels at dialysis initiation had the greatest death risk.
VDRAs Do Not Lower Cardiovascular Event Risk in HD
Trial results do not support use of vitamin D receptor activators to prevent cardiovascular events in patients with end-stage renal disease and low intact parathyroid hormone levels.
Ankle-Brachial Index Predicts Vascular Calcification in SHPT
Analyses demonstrated that an ABI of 1.79 correlated with radiographic evidence of calcified vessels.
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