Hyperphosphatemia

Ferric Citrate May Lessen Anemia in Advanced CKD

Publish Date July 9, 2019

The phosphate binder ferric citrate coordination complex may mitigate anemia, elevated phosphorus, and FGF23 in patients with advanced CKD, new research suggests.

CV Event Rates Similar for Calcium, Noncalcium Phosphate Binder Users

Publish Date May 15, 2019

In a study, the risks for cardiovascular events and all-cause mortality were only a nonsignificant 4% lower for sevelamer vs calcium acetate recipients older than 65 years initiating hemodialysis.

Staying on Sucroferric Oxyhydroxide May Cut Hospitalization Rate

Publish Date May 10, 2019

Hemodialysis patients who stayed on the phosphate binder sucroferric oxyhydroxide for 2 years had fewer hospitalizations those who switched to another binder for 2 years.

Phosphate Binders May Have Other Gastrointestinal Effects

Publish Date April 16, 2019

According to preliminary research, phosphate binders may bind to helpful substances such as vitamin K, but also to harmful ones, such as lipopolysaccharides and advanced glycation end products.

Vitamin K Antagonists, Liver Dysfunction Implicated in Calciphylaxis

Publish Date April 10, 2019

In a small study, vitamin K antagonist use and liver dysfunction emerged as the most important factors in the development of calciphylaxis.

Review: Phosphate-Containing Meds Contribute to Phosphorus Load in CKD

Publish Date April 9, 2019

Researchers estimate that half of calcium channel blockers, for example, contain phosphorus as an excipient.

FGF23 Predicts Death, Cardiovascular Events in Hemodialysis

Publish Date April 8, 2019

In meta-analyses, elevated FGF23 correlated with 25% and 22% increased risks for all-cause mortality and cardiovascular events, respectively, among patients on maintenance hemodialysis.

Drug Treats Hyperphosphatemia Without Binding Phosphate

Publish Date March 14, 2019

In a phase 3 trial, tenapanor, which reduces paracellular phosphate transport in the intestine, lowered elevated serum phosphorus in patients on hemodialysis.

Elevated Phosphate Linked With Mortality in Peritoneal Dialysis

Publish Date March 11, 2019

In a new study, patients with serum phosphate levels above 1.78 mmol/L at the start of peritoneal dialysis had a nearly 2-fold increased risk of death.

Activated Charcoal May Delay Hyperphosphatemia

Publish Date March 5, 2019

In a 2-phased trial, hyperphosphatemia and is sequelae developed in a smaller proportion of patients taking activated charcoal compared with placebo recipients.