Elevated high-density lipoprotein (HDL) cholesterol protects against cardiovascular disease in the general population, but it may increase the risk of cardiovascular and all-cause mortality in hemodialysis patients, according to researchers.
In a study of 33,109 HD patients followed for up to 3 years, patients with HDL concentrations of 60 mg/dL or higher had a significant 8% and 5% increased risk of cardiovascular and all-cause mortality compared with patients with HDL concentrations of 30 mg/dL or higher but less than 60 mg/dL, researchers reported online ahead of print in Nephrology Dialysis Transplantation.
In addition, HDL levels below 30 mg/dL were associated with a significant 8% and 28% increased risk of all-cause and cardiovascular mortality. These associations were strongest in male patients, diabetics, and patients younger than 65 years.
The study, led by Kamyar Kalantar-Zadeh, MD, PhD, of the University of California Irvine, showed that HDL levels of 50 mg/dL or higher but less than 60 mg/dL offered the best survival.