HealthDay News — There is considerable variation in adherence across medication classes for the treatment of type 2 diabetes (T2D), according to a review published in Diabetes, Obesity and Metabolism.

Andrew McGovern, BMBS, from the University of Surrey in Guildford, UK, and colleagues conducted a systematic literature review of observational studies comparing medication adherence or persistence between 2 or more glucose-lowering medications in individuals with T2D. Data were included for 48 studies.

The researchers found that adherence was better for sulfonylureas and thiazolidinediones compared with metformin (mean difference, 10.6% [95% confidence interval [CI], 6.5 to 14.7%] and 11.3% [95% CI, 2.7 to 20.0%], respectively). Compared with sulfonylureas, thiazolidinedione adherence was marginally better (mean difference, 1.5%; 95% CI, 0.1 to 2.9%). Adherence was better for dipeptidyl peptidase-4 inhibitors than sulfonylureas and thiazolidinediones. Compared with long-acting analogue insulins, glucagon-like peptide-1 receptor agonists had a higher odds ratio for discontinuation (1.95 [95% CI, 1.17 to 3.27]). Better persistence was seen for long-acting insulin analogues versus human insulins (mean difference, 43.1 days [95% CI, 22.0 to 64.2 days]). There was considerable variability in the methods for defining adherence and persistence.

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“Adherence varies considerably across different medication classes used for the treatment of T2D,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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McGovern A, Tippu Z, Hinton W, et al. A comparison of adherence and persistence by medication class in type 2 diabetes: A systematic review and meta-analysis. Diabetes Obes Metab. 2017 Nov 14. doi:10.1111/dom.13160