HealthDay News — For patients with diabetes, the presence of depression is associated with increased risk of developing chronic kidney disease (CKD), according to a study published online in Diabetes Care.

Marta Novak, MD, PhD, from the University of Toronto, and colleagues examined the correlation between depression and incident CKD, mortality, and incident cardiovascular events in US veterans with diabetes. A total of 933,211 patients with diabetes were identified among a nationally representative prospective cohort of more than 3 million US veterans with baseline estimated glomerular filtration rate (eGFR) of ≥60 mL/min/1.73m². At enrollment, 340,806 patients had depression.

The researchers found that patients with depression were younger, had higher eGFR, and had more comorbidities. Overall, 180,343 patients developed incident CKD. The risk of incident CKD was increased with depression (adjusted hazard ratio, 1.20). Depression was also linked to elevated all-cause mortality (adjusted hazard ratio, 1.25).

“Intervention studies should determine if effective treatment of depression in diabetic patients would prevent major renal and cardiovascular complications,” the authors write.

Related Articles


  1. Novak M, Mucsi I, Rhee CM, et al. Increased Risk of Incident Chronic Kidney Disease, Cardiovascular Disease, and Mortality in Diabetic Patients With Comorbid Depression. Diabetes Care. doi: 10.2337/dc16-0048.