In women, lower melatonin secretion is independently associated with a higher risk of developing type 2 diabetes, according to a study published published online in the Journal of the American Medical Association.
Ciaran J. McMullan, MD, from Channing Division of Network Medicine in Boston, and colleagues conducted a case-control study nested within the Nurses’ Health Study cohort. From 2000 to 2012, 370 women were identified who developed type 2 diabetes, as well as 370 matched controls.
The researchers found that, among cases, the median urinary ratios of 6-sulfatoxymelatonin to creatinine were 28.2 ng/mg and 36.3 ng/mg among controls. The risk of diabetes increased by 48% with each unit decrease in the estimated log ratio of 6-sulfatoxymelatonin to creatinine). Diabetes was twice as likely to develop in women in the lowest category as in women in the highest ratio category of 6-sulfatoxymelatonin to creatinine. The study revealed an estimated diabetes incidence rate of 4.27 cases/1,000 person-years compared for women in the highest category of melatonin secretion versus 9.27 cases/1,000 person-years in the lowest category.
“Lower melatonin secretion was independently associated with a higher risk of developing type 2 diabetes,” the authors wrote.