(HealthDay News) — For patients with heart failure and reduced ejection fraction, dapagliflozin is associated with a lower risk for worsening heart failure or death from cardiovascular causes, regardless of the presence of type 2 diabetes, according a study published online in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the European Association for the Study of Diabetes, held from Sept. 16 to 20 in Barcelona, Spain.

John J.V. McMurray, MD, from the University of Glasgow in the United Kingdom, and colleagues randomly assigned 4744 patients with New York Heart Association class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either dapagliflozin (2373 patients) or placebo (2371 patients) in addition to recommended therapy.

The researchers found that the primary outcome of worsening heart failure or cardiovascular death occurred in 16.3 and 21.2% of patients in the dapagliflozin and placebo groups, respectively, during a median of 18.2 months (hazard ratio, 0.74). A first worsening heart failure event occurred in 10.0 and 13.7%, respectively (hazard ratio, 0.70). Death from cardiovascular causes occurred in 9.6 and 11.5% of patients in the dapagliflozin and placebo groups, respectively (hazard ratio, 0.82), while 11.6 and 13.9%, respectively, died from any cause (hazard ratio, 0.83). Findings were similar for patients with and without diabetes.

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“Dapagliflozin was as effective in the 55% of patients without type 2 diabetes as in those with diabetes,” the authors write.

The study was funded by AstraZeneca, the manufacturer of dapagliflozin.


McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. doi:10.1056/NEJMoa1911303

Fang JC. Heart-Failure Therapy — New Drugs but Old Habits? N Engl J Med. doi:10.1056/NEJMe1912180

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