Low hemoglobin levels are associated with an elevated risk of contrast-induced nephropathy (CIN) following administration of iodinated contrast media, data suggest.

Jinzhong Xu, MD, of Wenzhou Medical University, Wenling, Zhejiang, China, and colleagues divided 841 patients undergoing coronary angiography and/or percutaneous coronary intervention (CAG/PCI) into 2 groups: patients with low hemoglobin levels (less than 120 g/L for men, less than 110 g/L for women) and normal levels (120–160 g/L for men, 110–150 g/L for women). CIN developed in 14.7% of patients with low hemoglobin levels compared with 5% of those with normal levels. On multivariable analysis, low hemoglobin was associated with a 3-fold increased risk of CIN, according to a report in Experimental and Therapeutic Medicine (2016;12:603-610).

The investigators determined that the optimal cut-off at which the hemoglobin level resulted in a high probability of developing CIN was 115.5 g/L in men and 111.5 g/L in women.

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