Contrast Nephropathy

Gadavist Imaging Bulk Package Approved for Multi-Patient Dosing

Publish Date August 19, 2020

Gadavist® Imaging Bulk Package is supplied as 604.72mg/mL of gadobutrol in 30mL and 65mL multidose containers.

Recommendations for Use of IV Iodinated Contrast Media Updated

Publish Date March 3, 2020

Radiologists and clinicians should weigh the relative benefits and risks of using IV contrast in patients with eGFRs less than 30 mL/min/1.73 m2, according to a consensus statement.

Renal Outcomes Not Worsened by Omitting Hydration Prior to Contrast-Enhanced CT

Publish Date February 20, 2020

Withholding prehydration with sodium bicarbonate from patients with CKD stage 3 undergoing nonemergent contrast-enhanced computed tomography does not compromise renal safety, a study found.

Data Support Group II Gadolinium-Based Contrast Use in Advanced Kidney Disease

Publish Date February 5, 2020

The potential diagnostic harms of withholding group II gadolinium-based contrast agents may outweigh the risk of nephrogenic systemic fibrosis in advanced CKD patients, according to investigators.

Hepcidin May Enable Early Ruling Out of Contrast-Induced AKI

Publish Date March 6, 2019

Serum hepcidin rises significantly as early as 4 and 8 hours after percutaneous coronary intervention.

Gadolinium-Based Contrast May Up Acute Kidney Injury Risk in CKD

Publish Date November 16, 2018

The risk of post-contrast acute kidney injury increased with decreasing renal function.

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

Publish Date January 31, 2018

No patient had a 25% or greater rise in serum creatinine 48 hours after receiving a median 13 mL of contrast for diagnostic coronary angiography, with an additional 13 mL for percutaneous coronary intervention.

Nicorandil May Prevent Contrast-induced Nephropathy

Publish Date January 17, 2018

Nicorandil significantly reduced contrast-induced nephropathy by 62%, compared with controls.

IV Sodium Bicarbonate Does Not Reduce AKI Risk After Angiography

Publish Date November 13, 2017

Contrast-associated acute kidney injury occurred in 9.5% and 9.1% of patients receiving IV sodium bicarbonate and acetylcysteine, respectively, rates which did not differ significantly from the 8.3% rate among those receiving IV sodium chloride.

AKI More Likely After Intracoronary Versus IV Contrast Delivery

Publish Date November 4, 2017

In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.