Waist-to-height ratio is independently associated with an increased risk of chronic kidney disease (CKD) in overweight patients with type 2 diabetes, according to a new study.

In these patients, each standard deviation increase in waist-to-height ratio is associated with a 70% increased odds of CKD after adjusting for confounders, researchers led by Kristina Blaslov, MD, of the University of Zagreb School of Medicine in Zagreb, Croatia, reported online in Endocrine Research.

The study included 125 overweight patients with type 2 diabetes with a mean age of 58 years. Of these, 36 (28.8%) met diagnostic criteria for CKD: an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2 using the Chronic Kidney Disease Epidemiology Collaboration formula and/or albuminuria (30 mg/24 h or greater in 2 measurements at least 3 months apart). The researchers determined urine albumin excretion (UAE) as the mean of 24-hour urine from 2 consecutive days.

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Patients with CKD had a higher waist-to-height ratio and waist circumference than those without CKD, but only waist-to-height ratio correlated negatively with eGFR and positively with UAE.

Dr. Blaslov and her colleagues noted that their results indicate that waist-to-height ratio may be of greater importance as a risk factor for the development of CKD than other anthropometric parameters that indicate obesity, such as central obesity.