(HealthDay News) — Distinct trajectories of chronic kidney disease (CKD) may predict subsequent health outcomes, according to a study published online in the Clinical Journal of the American Society of Nephrology.

Moustapha Faye, MD, from CHRU-Nancy in France, and colleagues aimed to identify subgroups within the 5-year trajectories of symptom evaluation among 2787 participants with estimated glomerular filtration rate <60 mL/min/1.73 m2 enrolled in the CKD-Renal Epidemiology and Information Network (CKD-REIN) cohort study from July 2013 to May 2016. Symptoms were assessed annually and 9121 measures were reported over follow-up.

The researchers found that the prevalence of symptoms ranged from 24% for chest pain to 83% for fatigue; at least one symptom was reported by 98% of participants. Overall, 690 patients initiated kidney replacement therapy (KRT) and 490 died before initiating KRT after a median follow-up of 5.3 years. Two profiles of symptoms trajectories were identified: worse symptom score and worsening trajectory, which was characterized by a low initial symptoms score that worsened more than 10 points over time, a better symptom score, and a stable trajectory (31 and 69%, respectively). More risk factors for CKD progression at baseline, worse quality of life, and a higher risk of KRT and death before KRT were seen for participants in the worse symptom score and worsening trajectory group compared with other participants.

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“It is possible to actively monitor symptoms and classify patients according to their progression,” Faye said in a statement. “This active symptom tracking will allow early therapeutic interventions to be planned to help manage different symptoms.”

CKD-REIN has been supported by a public-private partnership with several pharmaceutical companies. Several authors disclosed financial ties to these and other pharmaceutical companies.

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