Statin use is associated with an increased risk of acute and chronic kidney disease, researchers reported online in the American Journal of Cardiology.

Tushar Acharya, MD, of the University of California San Francisco–Fresno Medical Education Program, Fresno, Calif., and colleagues propensity score matched 6,342 statin users with 6,342 non-users. After a follow-up of 8.4 years, statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.

“These findings are cautionary and suggest that long-term effects of statins in real-life patients may differ from shorter term effects in selected clinical trial population,” the authors concluded.

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