(HealthDay News) — Potentially nephrotoxic medications are prescribed at a higher rate to children with versus without chronic kidney disease (CKD), according to a study published online in the Clinical Journal of the American Society of Nephrology.

Claire E. Lefebvre, MD, from the Centre Hospitalier Universitaire Sainte-Justine in Montreal, and colleagues conducted a retrospective, matched population-based cohort study of patients aged less than 18 years registered at a general practice to determine the prevalence and rates of primary care prescriptions for potentially nephrotoxic medications. Children with a clinical code indicating an incident diagnosis of CKD were matched to patients without CKD in a 1:4 ratio; data were included for 1018 incident CKD cases and 4072 non-CKD matched controls.

The researchers found that during follow-up, 26 and 15% of patients with and without CKD, respectively, were prescribed one or more potentially nephrotoxic medications. The overall rate of nephrotoxic medication prescriptions was 71 and 8 per 100 person-years in patients with and without CKD, respectively (adjusted rate ratio, 4.1).

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“Potentially nephrotoxic medications appear to be prescribed at high rates to pediatric patients with CKD,” the authors write. “Although their use may sometimes be justified, there is an apparent need for increased awareness of their harmful potential in this high-risk patient group.”

One author disclosed financial ties to the pharmaceutical industry; a second author disclosed ties to a health care company.


Lefebvre CE, Filion KB, Reynier P, Platt RW, and Zappitelli M. Primary Care Prescriptions of Potentially Nephrotoxic Medications in Children with CKD.
Clin J Am Soc Nephrol. December 2019, CJN.03550319. doi:10.2215/CJN.03550319

Goldstein SL Keep Children with CKD Safe from Inappropriate Prescribing. Clin J Am Soc Nephrol. December 2019, CJN.13641119. doi:10.2215/CJN.13641119

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