(HealthDay News) — Lymphoma survivors are at substantial long-term risk for chronic kidney disease (CKD) development, according to a study published online in Leukemia & Lymphoma.
Sanjal H. Desai, MD, from the Medstar Washington Hospital Center in Washington, DC, and colleagues describe patterns of long-term CKD in lymphoma survivors. At diagnosis and years 1, 2, 5, and 10, glomerular filtration rate (GFR) was recorded.
The researchers found that among 397 patients (median age, 55.3 years; 54% male; 60% African-American), 42% had hypertension, 15% had diabetes mellitus, 13% had hyperuricemia, 86% received chemotherapy, and 14% had baseline CKD. Just under one-third of patients (31%) developed CKD within 10 years of lymphoma diagnosis. There was a significant increase noted in the probability of CKD development with time (23% at year 1 increased to 41% at year 10). The investigators observed a decline in GFR of 4.6 mL/min/per year. CKD was predicted by age, hypertension, hyperuricemia, and diabetes (in young patients).
“These findings underscore the need to monitor renal function in long-term lymphoma survivors and lay foundation for future prospective studies to define strategies to prevent CKD in lymphoma survivors,” the authors write.