Men have a greater lifetime risk for end-stage renal disease (ESRD) than women, according to a Canadian study.

In a study more than 2.8 million Alberta adults without ESRD, researchers found that, among individuals without ESRD at age 40, the lifetime risk of ESRD for men and women living into their 90s was 2.66% and 1.76%, respectively. This translates into approximately one in 40 men and one in 60 women, Brenda Hemmelgarn, MD, of Foothills Medical Centre in Calgary, Alberta, and colleagues reported online ahead of print in the Journal of the American Society of Nephrology.

The risks were higher among those with reduced kidney function. For subjects with an estimated glomerular filtration rate (eGFR) of 44-59 mL/min/1.73 m2, the lifetime risk for ESRD was 7.51% for men versus 3.21% for women. For individuals with relatively preserved kidney function (eGFR 60-89), the lifetime risks for men and women were 1.01% and 0.63%, respectively.

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“These population-based estimates may assist individuals who make decisions regarding public health policy,” the investigators concluded.