Urologic procedures to treat patients with urolithiasis increase the risk for elevated serum creatinine, but they do not appear to increase the incidence of chronic kidney disease (CKD), according to a new study.

Matthew D’Costa, MD, of Marshfield Clinic in Marshfield, Wis., and colleagues conducted a retrospective observational cohort study that included 1,340 patients diagnosed with urolithiasis, of whom 446 (33.28%) underwent urologic procedures for kidney stones. The mean follow-up to the last clinic visit or death was 9.8 years for the procedure group and 9.5 years for the patients who did not have procedures.

These patients who underwent procedures had a significant 49% increased risk for elevated serum creatinine compared with those who did not undergo procedures, after adjusting for age, gender, and comorbidities, the investigators reported online in Clinical Medicine & Research. The researchers found no significant between-group difference in the incidence of CKD or death from any cause.

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Although elevated serum creatinine may be the result of procedural intervention, it is just as likely, if not more so, to be the result of renal injury secondary to the urolithiasis event itself, the investigators wrote.

“Urologic procedures may protect those with more significant urolithiasis events from long-term renal dysfunction,” the authors concluded.

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