(HealthDay News) — Severely impaired left ventricular (LV) global longitudinal strain (GLS) is associated with worse prognosis in predialysis and dialysis patients, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

Liselotte C.R. Hensen, MD, from Leiden University Medical Center in the Netherlands, and colleagues measured LV GLS in a retrospective cohort of predialysis and dialysis patients (chronic kidney disease stage 3b to 5) who underwent clinically indicated echocardiography. They divided patients according to quartiles of LV GLS.

Sixty-five and 35% of the 304 patients were in predialysis and dialysis, respectively. The researchers found that 34% of patients underwent renal transplantation during a median follow-up of 29 months, and 36% died. Compared with other groups, patients with the worst function (LV GLS ≤10.6%) showed significantly worse prognosis. After adjustment for age, gender, albumin levels, atrial fibrillation, and renal transplantation, LV GLS ≤10.6% was significantly associated with increased risk of all-cause mortality (hazard ratio, 2.18).

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“In conclusion, in predialysis and dialysis patients, severely impaired LV GLS is independently associated with an increased risk of mortality,” the authors write.

One author disclosed financial ties to Abbott Vascular.

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  1. Hensen LCR, Goossens K, Delgado V, et al. Prognostic Implications of Left Ventricular Global Longitudinal Strain in Predialysis and Dialysis Patients. Am J Cardiol. 1 Aug 2017. doi: 10.1016/j.amjcard.2017.04.054