Higher serum uric acid (SUA) levels increase the risk of chronic kidney disease (CKD), according to Korean researchers.
In a 10.2-year prospective cohort study involving 14,939 individuals aged 20-84 years who completed medical questionnaires and medical examinations, Yejin Mok, MD, and colleagues at Yonsei University in Seoul found that men and women in the highest quartile of SUA had a 2.1 times and 1.3 times increased risk of CKD, respectively, compared with their counterparts in the lowest quartile, after controlling for age, life style and cardiovascular risk factors.
Findings appear in a report in Nephrology Dialysis Transplantation (published online ahead of print).
The authors noted that both SUA and CKD are associated with cardiovascular disease (CVD) risk. Their finding of an independent association between higher SUA levels and CKD risk suggests that at least part of the reported association between SUA and cardiovascular disease may be connected with CKD.