High intake of dietary fiber is associated with better kidney function and reduced inflammation among community-dwelling elderly men, according to a Swedish study.
Researchers calculated dietary fiber intake from 7-day dietary records kept by 1,110 men aged 70-71 years who participated in the Uppsala Longitudinal Study of Adult Men. They calculated eGFR using serum cystatin C concentrations.
After adjusting for potential confounders, each 10 g/day increase in dietary fiber intake was independently associated with a statistically significant 2.6 mL/min/1.73 m2 increment in estimated glomerular filtration rate (eGFR), a team led by Juan Jesús Carrero, MD, of Karolinska University Hospital in Stockholm, reported online ahead of print in the Clinical Journal of the American Society of Nephrology.
In addition, compared with individuals in the lowest quartile of dietary fiber intake (14.5 g/day or less), those in the highest quartile (greater than 19.2 g/day) had a statistically significant 35% decreased odds of having elevated C-reaction protein (greater than 3 mg/L), a systemic marker of inflammation.
Higher fiber intake was associated with lower all-cause and cancer-related mortality in subjects with kidney dysfunction (eGFR below 60 mL/min/1.73 m2).
In these individuals, each 10 g/day increase in fiber intake was associated with a statistically significant 42% decreased risk of death from any cause and 75% decreased risk of cancer-related death. The researchers observed no statistically significant association between fiber intake and cardiovascular-related death.