Acute exercise may benefit children and adolescents with chronic kidney disease (CKD) via anti-inflammatory effects, according to the findings of a Canadian pilot study published online ahead of print in Pediatric Nephrology.
Keith K Lau, MD, and colleagues at McMaster University in Hamilton, Ontario, studied 9 children and adolescents with CKD stages 3-5 who performed a graded exercise test to determine peak oxygen uptake (VO2 peak). Following a 10-minute break, subjects cycled for 20 minutes at 50% of VO2 peak.
Investigators collected blood samples before and after the exercise period to determine complete blood counts, natural killer cell (NKbright and NKdim) counts, and circulating progenitor cells (CPC) counts.
Complete blood counts, NKdim counts, and CPC counts remained unchanged with exercise, but NKbright cell counts increased. Results also showed a non-significant trend toward increased interleukin-6, decreased tumor necrosis factor-ɑ, and an increase in the IL-6:TNF-ɑ ratio.