Acute exercise may benefit children and adolescents with chronic kidney disease (CKD) via anti-inflammatory effects, according to the findings of a Canadian pilot study published online ahead of print in Pediatric Nephrology.

Keith K Lau, MD, and colleagues at McMaster University in Hamilton, Ontario, studied 9 children and adolescents with CKD stages 3-5 who performed a graded exercise test to determine peak oxygen uptake (VO2 peak). Following a 10-minute break, subjects cycled for 20 minutes at 50% of VO2 peak.

Investigators collected blood samples before and after the exercise period to determine complete blood counts, natural killer cell (NKbright and NKdim) counts, and circulating progenitor cells (CPC) counts.

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Complete blood counts, NKdim counts, and CPC counts remained unchanged with exercise, but NKbright cell counts increased. Results also showed a non-significant trend toward increased interleukin-6, decreased tumor necrosis factor-ɑ, and an increase in the IL-6:TNF-ɑ ratio.