Exercise training and lifestyle intervention has beneficial effects on cardiorespiratory fitness, body composition, and diastolic function in patients with moderate chronic kidney disease (CKD), according to research published online in the Clinical Journal of the American Society of Nephrology.

Erin J. Howden, Ph.D., of the University of Queensland in Australia, and colleagues randomly assigned 90 patients with stage 3 to 4 CKD to either lifestyle changes, including exercise training (intervention group), or standard care (control group) for 12 months. Peak oxygen uptake was used as the measure of cardiorespiratory fitness.

The researchers found that among the 72 patients who completed follow-up (36 in each group), those receiving the intervention exhibited significant improvements compared with those receiving standard care, including increase in peak oxygen uptake, small amount of weight loss, and improvement in diastolic function. No change in blood pressure, lipid levels, or systolic function was observed during the intervention.

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“In this study of patients with moderate CKD and well managed cardiovascular risk factors, randomization to the intervention led to significant improvements in cardiorespiratory fitness, body composition, and cardiovascular parameters at 12 months,” the authors write.