As diabetic patients’ renal function decreases, their risk of diabetic foot syndrome (DFS) increases, a study finds.

Each 10 mL/min decrease in estimated glomerular filtration rate (eGFR) was associated with a 30% increased risk of DFS in type 1 diabetes patients and a 13% increased risk in type 2 diabetes patients, according to a report in Nephrology Dialysis Transplantation (2009;24:1896-1901).  

“Diabetic patients with CKD should be considered as a high-risk group for the development of DFS and should therefore be regularly screened for DFS during every office visit,” the researchers wrote.

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Gunter Wolf, MD, and his colleagues at the University of Jena in Jena, Germany, studied 899 patients with type 1 diabetes and 4,007 with type 2 diabetes. Forty-six of the type 1 patients (5.1%) and 532 of the type 2 patients (13.2%) had DFS.

Among type 1 patients, those with DFS had significantly higher serum creatinine levels, lower eGFR, higher hemoglobinA1c (HbA1c) levels, and higher systolic BP than those without DFS. Among the type 2 patients, those with DFS were significantly older, had a higher HbA1c, a longer duration of diabetes, a lower eGFR, and higher serum creatinine levels compared with those without DFS.