Type 2 diabetes develops at a higher rate among patients with chronic kidney disease (CKD) compared with the general population, investigators reported online ahead of print in the American Journal of Kidney Diseases.

In a study of 1713 participants in the Chronic Renal Insufficiency Cohort study without type 2 diabetes at baseline, Christopher Jepson, PhD, from the University of Pennsylvania in Philadelphia, and colleagues found an overall type 2 diabetes incidence rate of 17.81 cases per 1000 person-years. By comparison, the incidence rate observed in most general population cohort studies typically range from 4 to 14 cases/per 1000 person-year, Dr Jepson’s team wrote.

The investigators defined the presence of type 2 diabetes as a fasting blood glucose level of 126 mg/dL or less or a prescription for insulin or oral hypoglycemic agents.

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The only factors that predicted development of type 2 diabetes were baseline glycemic control and family history of diabetes.

The authors concluded that the markedly higher rate of type 2 diabetes among patients with CKD compared with the general population supports “the need for greater vigilance in this population.”


Jepson C, Hsu JY, Fischer MJ, et al. Incident type 2 diabetes among individuals with CKD: Findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis. 2018; published online ahead of print.