Healthy adults who habitually consume one or more cups of coffee daily may reduce their risk of chronic kidney disease (CKD), according to new study findings published in the American Journal of Medicine.
Of 8717 participants (mean age 52 years) with an estimated glomerular filtration rate above 60 mL/min/1.73 m2 from the Korean Genome and Epidemiology Study, 9.5% developed CKD over a mean 11 years, Seung Hyeok Han, MD, PhD, of Yonsei University in Seoul, South Korea, and his colleagues reported. In a multivariable Cox model, those who drank 1 cup of coffee or 2 or more cups daily had 24% and 20% lower risks of developing CKD, respectively. The researchers adjusted for blood pressure and major contributors to CKD, including hypertension, cardiovascular disease, and diabetes. They also accounted for caffeine intake from tea and chocolate, although not other caffeine-containing foods.
Coffee may have positive hemodynamic effects on vascular health, according to Dr Han’s team. They observed that baseline blood pressure decreased as coffee intake increased. This lower systemic blood pressure might lower glomerular pressure and lead to less glomerular hyperfiltration. Coffee also may contain compounds with antioxidant and anti-inflammatory effects.
Study limitations included lacked information on the types of coffee consumed, whether caffeinated or decaffeinated, instant mixed, or with dairy.
Hyun Jhee J, Heon Nam K, An SY, et al. Effects of coffee intake on incident chronic kidney disease: Community-based prospective cohort study. Am J Med. DOI: 10.1016/j.amjmed.2018.05.021