C-reactive protein (CRP) predicts development of proteinuria in a screened cohort, according to Japanese researchers.
Kunitoshi Iseki, MD, of the University Hospital of the Ryukyus in Okinawa, and collaborators analyzed data from 20,077 individuals in the Okinawa General Health Maintenance Association registry who were examined between 2004 and 2006. The prevalence of dipstick-positive proteinuria increased from 5.2% in subjects with a low CRP level (less than 0.10 mg/dL) to 12.3% in those with high CRP levels (0.30-0.90 mg/dL). CRP values did not affect the mean estimated glomerular filtration rate.
The investigators examined the relationship between baseline CRP and the development of proteinuria among those screened in 2004. Of 8,315 subjects without proteinuria who were examined again in 2006, 370 (4.4%) had developed proteinuria. Compared with subjects who had a CRP level below 0.10 mg/dL, those with a CRP level of 0.30-0.90 mg/dL had a 43% increased odds of developing proteinuria, after adjusting for multiple variables, the researchers reported online in Nephron Clinical Practice. The authors concluded that screened individuals with high CRP levels “may need to be followed up carefully despite the absence of traditional risk factors for proteinuria.”