Increased difference in systolic blood pressure (SBP) between arms is an independent predictor of chronic kidney disease (CKD) in the general population, according to a recent study conducted in Korea.

The finding is from a retrospective study of 8780 adult patients who had bilateral blood pressure measured sequentially and repeatedly at an initial visit. None of the patients had CKD at baseline. Patients who had an SBP difference of at least 15 mm Hg were considered to have increased inter-arm SBP difference (IASBPD). The investigators defined CKD as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2.

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During a mean follow-up period of 8.5 years, CKD developed in 96 (16.5%) of 581 patients with IASBPD and 1037 (12.6%) of those without IASBPD, Gwang-Sil Kim, MD, and colleagues at Inje University College of Medicine in Seoul, reported online ahead of print in the Journal of Hypertension. IASBPD was associated with a significant 27% increased risk of CKD compared with the absence of IASBPD after adjusting for potential confoundings, including age, sex, diabetes, hypertension, and obesity.


Kim GS, Byun YS, Lee HY, et al. Difference in SBP between arms is a predictor of chronic kidney disease development in the general Korean population. J Hypertens. 2018; published online ahead of print.