Cardiovascular events increase the risk of end-stage renal disease (ESRD) and death prior to ESRD among patients with stage 3-5 chronic kidney disease, a study found.

A team led by David Naimark, MD, of the University of Toronto, conducted a retrospective study of 2,964 patients referred to a nephrology clinic at Sunnybrook Health Sciences Centre in Toronto. Cardiovascular (CV) events (heart failure, myocardial infarction, or stroke) occurred in 447 patients (15%) and ESRD developed in 318 (11%), according to findings published online ahead of print in Circulation. In addition, 446 patients (15%) died prior to ESRD. A CV event increased patients’ risk of ESRD and all-cause mortality (ACM) prior to ESRD by 5.3 times and 4.1 times, respectively.

“CV events are common patients with CKD stages 3-5 and are associated with a substantial increase in the risk of ESRD and ACM prior to ESRD,” the authors concluded. “Intensive primary and secondary prevention strategies may help attenuate this risk.”

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