Kidney disease is a global public health problem, affecting over 750 million persons worldwide.1,2 The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural and political factors leading to significant disparities.3 World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight these disparities and emphasize the role of public policies and organizational structures in addressing them.
Burden of Kidney Disease
Availability of data reflecting the full burden of kidney disease varies substantially worldwide.4 While several countries have national data collection systems, particularly for end stage renal disease (ESRD), high quality data on non-dialysis chronic kidney disease (CKD) is limited, and often the quality of ESRD data is quite variable across settings. Incorporating kidney disease surveillance parameters in existing chronic disease prevention programs might enhance global efforts towards high quality information on kidney disease burden and attendant consequences.5
In addition to a need for functional surveillance systems, the global importance of kidney disease is yet to be widely acknowledged. For instance, the World Health Organization (WHO) Global Action Plan for the Prevention and Control of Non-Communicable Diseases (NCDs) (2013)6 focuses on cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes, but not kidney disease. This is quite concerning as estimates from the Global Burden of Disease study in 2015 showed that around 1.2 million people were known to have died of CKD,7 and over 2 million people died in 2010 because they had no access to dialysis. It is estimated that another 1.7 million die from acute kidney injury (AKI) on an annual basis.8,9 It is possible, therefore, that kidney disease may contribute to more deaths than the four main NCDs targeted by the current NCD Action Plan.
Health Policies and Financing of Kidney Disease Care
Due to the complex and costly nature of kidney disease care, its provision is tightly linked with the public policies and financial status of individual countries. In several high-income countries, universal health care is provided by the government and includes CKD and ESRD care. In others, such as the United States, ESRD care is publically financed for citizens, however, optimal treatment of CKD and its risk factors may not be accessible for persons lacking health insurance, and regular care of undocumented immigrants with kidney disease is not covered. In low- and lower-middle-income countries, neither CKD nor ESRD care may be publically financed and CKD prevention efforts are often limited. In several such countries, collaborations between public and private sectors have emerged to provide funding for RRT.10
In many settings, individuals with advanced CKD shoulder substantial financial burden. A systematic review of 260 studies including patients from 30 countries identified significant challenges including: fragmented care of indeterminate duration, reliance on emergency care, and fear of catastrophic life events because of diminished financial capacity to withstand them.11 Challenges may be even greater for families of children with ESRD, as many regions lack qualified pediatric care centers.
Organization and Structures for Kidney Disease Care
The lack of recognition and therefore absence of a global action plan for kidney disease partly explains the substantial variation in structures and capacity for kidney care around the globe. In 2017, the International Society of Nephrology collected data on country-level capacity for kidney care delivery using a survey, the Global Kidney Health Atlas (GKHA),4 which aligned with the WHO’s building blocks of a health system.13 The GKHA highlights limited awareness of kidney disease and its consequences and persistent inequities in resources required to tackle the burden of kidney disease across the globe. For example, CKD was recognized as a health care priority by government in only 36% of countries that participated in this survey, and priorities were inversely related to income level: CKD was a healthcare priority in more than half of low- and lower-middle-income countries, but in less than 30% of upper-middle- and high-income countries.
On capacity and resources for kidney care, many countries still lack access to basic diagnostics, a trained nephrology workforce, universal access to primary health care, and RRT. Low- and lower-middle-income countries, especially in Africa, had limited services for the diagnosis, management, and monitoring of CKD at the primary care level, with only 12% having serum creatinine measurement including estimated glomerular filtration rate. Across all world countries, availability of services at the secondary/tertiary care level was considerably higher than at the primary care level.
Renal Replacement Therapies
The distribution of RRT technologies varied widely. On the surface, all countries reported having chronic hemodialysis services, and more than 90% of countries reported having acute hemodialysis. However, access to and distribution of RRT across countries and regions was highly inequitable, often requiring prohibitive out-of-pocket expenditure, particularly in low-income regions. For instance, more than 90% of upper-middle- and high-income countries reported having chronic peritoneal dialysis services, whereas these services were available in 64% and 35% of low- and lower-middle-income countries, respectively. As expected, low-income countries had the lowest availability of kidney transplant services, with only 12% reporting availability, and live donors as the only source.
Workforce for Kidney Care
Considerable international variation was also noted in the distribution of the kidney care workforce, particularly nephrologists. The lowest density (<5 nephrologists per million population) was very common in low-income countries, whereas the highest density (nephrologists per million population) was reported mainly in high-income countries.4,14,15 Quite encouragingly, the number of nephrologists and nephropathologists is rising in low- and lower-middle-income countries, in part thanks to fellowship programs supported by international nephrology organizations.16,17
Most countries reported nephrologists as primarily responsible for both CKD and AKI care. Primary care physicians (PCPs) had more responsibility for CKD care than AKI care. Intensive care specialists were primarily responsible for AKI in 75% of countries, likely because AKI is typically treated in hospitals. However, only 45% of low-income countries reported that intensive care specialists were primarily responsible for AKI, compared to 90% of high-income countries. For other care providers essential for kidney care, provider shortages were highest for renal pathologists (86% of countries reported a shortage), vascular access coordinators (81%), and dietitians (78%), and the shortages were more common in low-income countries.
How could this information be used to mitigate existing barriers to kidney care? First, basic infrastructure for services must be strengthened at the primary care level for early detection and management of AKI and CKD across all countries.18 Second, whilst optimal kidney care should obviously emphasize prevention to reduce adverse consequences of kidney disease at the population level, countries (particularly low- and lower-middle-income countries) should be supported at the same time to adopt more pragmatic approaches in providing RRT. For example, acute peritoneal dialysis could be an attractive modality for AKI, as this is as effective as hemodialysis, requires far less infrastructure, and can be performed with solutions and catheters adapted to local resources.19,20 Third, kidney transplantation should be encouraged through increased awareness among the public and political leaders across countries, as this is the clinically optimal modality of RRT and it is also cost-effective, provided that costs of the surgery and long-term medication and follow-up are made sustainable through public (and/or private) funding.21
Socially disadvantaged individuals experience a disproportionate burden of kidney disease worldwide. The provision of and delivery of kidney care varies widely across the world. Achieving universal health coverage worldwide by 2030 is one of the WHO Sustainable Development Goals.22 While universal health coverage may not include all elements of kidney care in all countries, understanding what is feasible and important for a country or region with a focus on reducing the burden and consequences of kidney disease would be an important step towards achieving kidney health equity.
This article was published in Kidney International volume 95, pages 242-248, and reprinted concurrently in other journals. The articles cover identical concepts and wording, but vary in minor stylistic and spelling changes, detail, and length of manuscript in keeping with each journal’s style. Any of these versions may be used in citing this article.
1. GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. Oct 8 2016;388(10053):1603-1658.
2. Bikbov B, Perico N, Remuzzi G, on behalf of the GBD Genitourinary Diseases Expert Group. Disparities in Chronic Kidney Disease Prevalence among Males and Females in 195 Countries: Analysis of the Global Burden of Disease 2016 Study. Nephron. 2018;139(4):313-318.
3. Crews DC, Liu Y, Boulware LE. Disparities in the burden, outcomes, and care of chronic kidney disease. Curr Opin Nephrol Hypertens. May 2014;23(3):298-305.
4. Bello AK, Levin A, Tonelli M, Okpechi IG, Feehally J, Harris D, et al. Global Kidney Health Atlas: A report by the International Society of Nephrology on the current state of organization and structures for kidney care across the globe. [Internet]. 2017. [cited 24 July 2018]. Available from: https://www.theisn.org/images/ISN_advocacy/GKHAtlas_Linked_Compressed1.pdf.
5. Levin A, Tonelli M, Bonventre J, Coresh J, Donner JA, Fogo AB, et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet. 21 Oct 2017;390(10105):1888-1917.
6. World Health Organization. Global Action Plan for the prevention and control of noncommunicable diseases. 2013-2020. [Internet]. 2013. [cited 22 August 2018]. Available from: https://www.who.int/nmh/events/ncd_action_plan/en/
7. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. Oct 8 2016;388(10053):1459-1544.
8. Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. May 16 2015;385(9981):1975-1982.
9. Mehta RL, Cerda J, Burdmann EA, Tonelli M, Garcia-Garcia G, Jha V, et al. International Society of Nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet. Jun 27 2015;385(9987):2616-2643.
10. Rizvi SA, Naqvi SA, Zafar MN, Akhtar SF. A kidney transplantation model in a low-resource country: an experience from Pakistan. Kidney Int Suppl (2011). May 2013;3(2):236-240.
11. Roberti J, Cummings A, Myall M, Harvey J, Lippiett K, Hunt K, et al. Work of being an adult patient with chronic kidney disease: a systematic review of qualitative studies. BMJ Open. Sep 4 2018;8(9):e023507.
12. Harambat J, Ekulu PM. Inequalities in access to pediatric ESRD care: a global health challenge. Pediatr Nephrol. Mar 2016;31(3):353-358.
13. World Health Organization. Monitoring the building blocks of health systems: a handbook of indicators and their measurement strategies. [Internet]. 2010 [cited 22 August 2018] Available from: http://www.who.int/healthinfo/systems/WHO_MBHSS_2010_full_web.pdf
14. Osman MA, Alrukhaimi M, Ashuntantang GE, Bellorin-Font E, Benghanem Gharbi M, Braam B, et al. Global nephrology workforce: gaps and opportunities toward a sustainable kidney care system. Kidney Int Suppl. Feb 2018. 8(2): 52-63.
15. World Health Organization. Global Health Observatory indicator views [Internet]. Most recent year. [cited 24 July 2018]. Available from: http://apps.who.int/gho/data/node.imr#ndx-P
16. Feehally J. The International Society of Nephrology (ISN). Roles & challenges in Africa and other resource-limited communities. Clin Nephrol. 2016 Supplement 1;86 (2016)(13):3-7.
17. Harris DC, Dupuis S, Couser WG, Feehally J. Training nephrologists from developing countries: does it have a positive impact? Kidney Int Suppl (2011). Aug 2012;2(3):275-278.
18. Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. Dec 2011;80(12):1258-1270.
19. Cullis B, Abdelraheem M, Abrahams G, Balbi A, Cruz DN, Frishberg Y, et al. Peritoneal dialysis for acute kidney injury. Perit Dial Int. Jul-Aug 2014;34(5):494-517.
20. Chionh CY, Soni SS, Finkelstein FO, Ronco C, Cruz DN. Use of peritoneal dialysis in AKI: a systematic review. Clin J Am Soc Nephrol. Oct 2013;8(10):1649-1660.
21. Muralidharan A, White S. The need for kidney transplantation in low- and middle-income countries in 2012: an epidemiological perspective. Transplantation. Mar 2015;99(3):476-481.
22. World Health Organization. Universal health coverage (UHC) – fact sheet. [Internet]. 2017. [cited 24 July 2017]. Available from: http://www.who.int/news-room/fact-sheets/detail/universal-health-coverage-(uhc).