Nutritional status is associated with abdominal aortic calcification (AAC) in patients with chronic kidney disease, researchers in Japan concluded in a paper published online ahead of print in the Circulation Journal.

In a study that enrolled 323 asymptomatic CKD and not on dialysis, Kazuhiro Harada, MD, and colleagues at Nagoya University Graduate School of Medicine in Nagoya, Japan, evaluated AAC using the aortic calcification index (ACI) determined on non-contrast computed tomography. They evaluated nutrition status using the geriatric nutritional risk index (GNRI) and divided patients into 3 groups according to GNRI tertile. The median aortic calcification index (ACI) decreased significantly with increasing GNRI tertile (15.5%, 13.6%, and 7.9%).  GNRI correlated significantly with ACI on multivariate analysis. In addition, low GNRI and high C-reactive protein (CRP) were significantly associated with severe AAC compared with high GNRI and low CRP.